College of Pharmacy, University of Karbala discussed a master dissertation on the effects of genetic polymorphisms in the ABCB1 transporter on the effectiveness of prednisolone treatment in patients with nephrotic syndrome by the postgraduate student, Ms. Rawan Azad Muhammad Rasool.

The dissertation aimed at evaluating the impact of genetic polymorphisms on children's response to treatment, particularly in cases that exhibit drug resistance to steroid drugs.

The dissertation confirmed a clear statistical correlation between certain genotypes and the level of response to treatment using advanced DNA analysis techniques.

The dissertation demonstrated that children carrying specific genetic variations were more responsive to treatment, while other genetic variations were associated with a significant increase in drug resistance, which explains the variability in treatment effectiveness among patients.

The dissertation recommended the inclusion of genetic testing in future treatment plans with the aim of early prediction of treatment effectiveness and determining the most appropriate doses for each case based on their genetic makeup, this would contribute to reducing side effects and achieving more accurate clinical outcomes.