The College of Pharmacy, University of Kufa discussed a Ph.D. thesis on designing, synthesizing and preliminary evaluation of the cytotoxicity of novel derivatives as potential inhibitors of the histone deacetylase-6 enzyme, by the postgraduate student, Mr. Ahmed Karim.
The thesis aimed at designing three classes of hybrid histone deacetylase inhibitors using capping units, binding systems, and zinc-linked groups to produce multifunctional inhibitors of the HDAC-6 enzyme.
The thesis demonstrated 109 hybrid molecules, the synthesis of 13 molecules, and their testing. Molecules CP.118, CP.123, and CP.125 demonstrated promising activity against breast cancer cells and good pharmacokinetic properties, with the potential use of folic acid as an enzyme inhibitor.
The thesis recommended the need for further in vivo experiments and structural modifications to the hybrid molecules to enhance their effectiveness and selectivity.
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